This gives the neural tissue a higher susceptibility to peroxidation ( Parkinsons Disease (PD) Pathogenesis: Role of Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation Parkinsons disease is a chronic, progressive neurodegenerative disorder involving the dopaminergic neurons in the substantia nigra pars compacta of the brain ( Dopamine Metabolism The neurotransmitter dopamine itself can be a source of oxidative stress
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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology ( As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Zha et al., 2024
10 It has been speculated that because oral administration of GSH leads to its inactivation by peptidases, it should not be possible to significantly increase plasma GSH concentrations with oral administration
Nat Commun (2022) 13(1):676
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