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Cambios hormonales tpicos con la prdida de peso: Mejora de la sensibilidad a la insulina y reduccin de la hiperinsulinemia Normalizacin de los niveles de leptina y adiponectina Reduccin de marcadores inflamatorios (protena C reactiva, IL-6) Adaptaciones en hormonas tiroideas (T3 libre puede disminuir ligeramente como adaptacin metablica) En hombres: aumento de testosterona y aumento de SHBG (globulina fijadora de hormonas sexuales) Estos cambios hormonales generalmente son beneficiosos y contribuyen a mejoras en la composicin corporal, la funcin sexual y el bienestar general

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doi: 10.1210/clinem/dgab905

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There are no data to suggest that routine endometrial sampling would be beneficial in asymptomatic women taking tamoxifen for breast cancer prevention

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27 Lastly, no randomized trials yet exist specifically investigating the utility of combining a GLP-1 RA and an SGLT-2 inhibitor in T2DM

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