Adults usually get 100 to 1,000 mcg of Vitamin B12
Drug-specific variables that may affect half-life Drug formulation (ie, modified or controlled release preparations extend half-life) How the drug behaves in the body (ie, zero-order, first-order, or multi-compartmental pharmacokinetics) How the drug is administered (half-life may be different with IV administration, compared to intranasal or oral administration) How the drug is cleared from the body (eg, kidneys, liver, lungs) If the drug accumulates in fat or other types of tissue If the drug binds to proteins or not Presence of metabolites or other drugs that may interact Properties of the drug, including molecule size, charge, and pKa The volume of distribution of a drug Other variables, such as if the drug is actively transported, is self-induced, or has saturation pharmacokinetics
Some studies have reported a difference between days of over 100 pmol/l Serum B12 concentrations may be influenced by specific changes in our genetic material, our DNA
Spatiotemporal control of acetyl-CoA metabolism in chromatin regulation
Front Cell Dev Biol
Eggs, especially the yolks, also provide B12
