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10.1016/j.clindermatol.2009.05.013 36 ZoppiN.ChiarelliN.RitelliM.ColombiM

Human clinical data limited to case reports and small trials, not large controlled studies

Foods and supplements that support glutathione production include nuts, legumes, beans, whey protein, milk thistle, eggs, beef, fish, poultry, flaxseed, spinach, and okra, along with cruciferous and allium vegetables such as broccoli, kale, onions, and garlic

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Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3beta/beta-Catenin signaling pathway

Plasma metabolic biomarkers include DL-glutamine, L-pyroglutamic acid, prostaglandin B1, and 3,4-dihydroxyhydrocinnamic acid, while Rikenellaceae RC9 , g_ (Clostridium)GCA900066575 , and g_Muriculum are identified as the principal biomarkers in gut microbiota (Zhou L