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Genetic factors play a significant role in how your body responds to semaglutidecertain variants in your GLP1R gene, for example, may influence both efficacy and tolerability

Side Effects: Gastrointestinal side effects, such as nausea, are common initially but can be managed by gradually adjusting the dosage

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The dosing schedule starts at 0.25mg weekly for the first month, then titrates up gradually to the maintenance dose