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1 In his commentary, Knowing the Difference Can Make a Difference , Dr Nasrallah states that anticholinergic agents are sometimes used for drug-induced parkinsonism because they may increase dopaminergic activity and help reverse the hypodopaminergic state of drug-induced parkinsonism and adds that using anticholinergic agents in TD may further exacerbate the hyperdopaminergic staterather than help it. Table 2 takes a closer look at both drug classes and their effects on patients with either movement disorder

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