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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al

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When NAD+ levels drop, our metabolic rate slows down, fat storage increases, and cellular aging accelerates

Tissue healing occurs in stages, and the subjective experience of improvement may not track linearly with objective tissue changes

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