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Moreover, genes associated with inflammation and fibrosis ( Tgfb1 , Tgfbi , Col1a1 , Col1a2 ), and extracellular matrix (ECM) remodeling ( Dcn , Bgn , Ecm1 , Lum ) were likewise diminished, suggesting a broader suppression of MASH-associated transcriptional programs in the absence of GPR146 (Supplementary Fig