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Overall, retatrutide led to significant and progressive weight loss over 48 weeks

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More than half of participants lost at least 20% of their body weight, a threshold associated with improvements in obesity-related comorbidities such as hypertension, dyslipidaemia, and obstructive sleep apnoea

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Marx N, Federici M, Schtt K, Mller-Wieland D, Ajjan RA, Antunes MJ, Christodorescu RM, Crawford C, Di Angelantonio E, Eliasson B, Espinola-Klein C, Fauchier L, Halle M, Herrington WG, Kautzky-Willer A, Lambrinou E, Lesiak M, Lettino M, McGuire DK, Mullens W, Rocca B, Sattar N, ESC Scientific Document Group (2023) 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes

Potential advantages associated with baxdrostat include: No gynecomastia reported No breast tenderness Minimal endocrine-related adverse effects Direct targeting of aldosterone excess Once-daily dosing convenience Important considerations: Hyperkalemia monitoring is still required Long-term cardiovascular outcomes are still being evaluated Cost may initially exceed generic MRAs such as spironolactone and eplerenone As hypertension management continues to evolve, it will be interesting to see where aldosterone synthase inhibition ultimately fits within future guideline-directed therapy