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In terms of mechanism, artesunate, curcumol, dihydroartemisinin and artemether mediate FTH1 degradation by increasing NCOA4, leading to ferritinophagy activation, iron accumulation, lipid peroxidation elevation, antioxidant capacity loss and ferroptosis occurrence
doi: 10.1016/j.freeradbiomed.2009.07.023 34 SainiRSinghS
Biochemical J 479:357384 Faramarzi F, Alimohammadi M, Rahimi A, Alizadeh-Navaei R, Shakib RJ, Rafiei A (2022) Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells: a systematic review and meta-analysis of in vitro and in vivo data
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In vitro, resveratrol treatment (50 M) of IgE/ 2,4-dinitrophenol -activated human mast cells and LPS-activated murine bone marrow derived mast cells showed reduced degranulation and expression of pro-inflammatory cytokines CCL2 and TNF- [186]
It is a base, e.g., for the deprotonation of ketones to form sodium enolates, phosphonium salts to form Wittig reagents, and formamidinium salts to form diaminocarbenes
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