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The primary reference is Raun and colleagues (Eur J Endocrinol, 1998), the paper that introduced the molecule and established the property it is known for

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Consider Antioxidant Supplements (If Recommended by a Doctor) Supplements like milk thistle, N-acetylcysteine (NAC), and alpha-lipoic acid (ALA) support liver detoxification and antioxidant levels

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PubMed Central, Shahrokhi, Seyedeh Z., et al

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While direct causal evidence in PCOS remains limited, this framework integrates endocrine, metabolic, and immunological dimensions to provide a structured lens for understanding how neutrophil and NET-mediated pathways could contribute to systemic and organ-specific dysfunction in affected women

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Other possible causal factors include "ultraviolet radiation and [an] increase [in] the normal skin microbes compared with non-affected individuals," explains Deirdre Connolly, a board-certified dermatologist in New York City

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