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PMC 4926480

Because most patients do not reach higher, more effective dosing levels until around weeks 8 through 12, stopping at the 2-month mark means ending treatment just as the medication begins delivering its strongest results

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Interestingly, sphingolipid metabolism emerged as a common pathway perturbed in the three mutants, although the number of genes in the clusters varied among the three mutants (Supplementary Fig

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