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Both activate AMPK

Researchers also suspect that some amino acids (the building blocks of protein) more efficiently increase GLP-1 than others, as demonstrated in one animal model

But on the flip side, glucagon also : Increases energy expenditure Promotes fat breakdown Prevents fat formation [6] So researchers hypothesized: Could we pair glucagon signaling with GLP-1 and GIP to amplify fat loss without spiking blood sugar

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[6] More weight loss and better tolerated are not the same axis

Slower titration or drug holidays help persistent cases