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It activates the GLP-1 receptor (like semaglutide), the GIP receptor (added in tirzepatide), and the glucagon receptor a third axis that increases resting energy expenditure and promotes hepatic fat oxidation

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However, not all antidepressants cause weight gain, and the extent varies

Semaglutide works by mimicking the activity of the naturally occurring hormone GLP-1, which regulates blood sugar levels and induces satiety, thereby reducing food intake