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On March 18, 2026, the FDA released a landmark draft guidance: "General Considerations for the Use of New Approach Methodologies (NAMs) in Drug Development." For small-to-midsize biotechs, this isn't just about ethicsits about capital efficiency and regulatory speed

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GLP-1RA, including exenatide/exendin-4 and liraglutide, have been tested in rodent models of alcoholism

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Ultimately, these metabolites are excreted in the urine (Figure 3)

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