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To determine if pharmacological manipulation of autophagy effects SIPS, we treated GSH-depleted cells with the autophagic inducer rapamycin and autophagic inhibitors 3-MA and Baf-A1

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In addition to allosteric activation of G6PDH, the G6PD gene is transcriptionally activated in response to oxidative stress

10.1038/ng1970 [DOI] [PubMed] [Google Scholar] 38.Cadenas S

The placenta should remain homeostatic and balanced across gestation with no evidence of oxidative stress (49, 50)