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Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain

One amino acid loses a hydrogen and oxygen from its carboxyl group (COOH) and the other amino acid loses a hydrogen from its amino group (NH 2 )

ER transcriptionally promotes the expression of SLC7A11 and SLC3A2 Given the observed association between ER and SLC7A11/SLC3A2 expression, we investigated how ER may regulate the expression SLC7A11 and SLC3A2

Sodium chloride is just common table salt

Could all this be due to the mutation

Combined with mutational analysis, molecular dynamics simulations and functional assays, we identify a conserved substrate-binding pocket that alternately accommodates G6P and Pi through electrostatic complementarity and domain-dependent interactions