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When something like berberine starts getting hyped, it's worth digging into the actual science to see whether it's legit or just another wellness trend that'll fade faster than your last juice cleanse

While many nerve-related issues are reversible, they are uncomfortable and can cause distress for patients

Dai et al

Intranigral LPS administration produces dopamine, glutathione but not behavioral impairment in comparison to MPTP and 6-OHDA neurotoxin models of Parkinsons disease

The symptoms that were listed (oligomenorrhea, hirsutism, biochemical and functional hyperandrogenism, etc.) were hyperandrogenism and others

The reason it is done fresh follows directly from the chemistry above