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The type 2 IGF receptor (IGF-2R / cation-independent mannose-6-phosphate receptor) does not signal in the classical sense but acts as a clearance sink for IGF-2 and, to a lesser extent, participates in ligand disposal

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Furthermore, a recent 2024 study highlighted the critical role of CD8 T-cell dysfunction in both ME/CFS and Long COVID, noting that these immune cells produce markedly less necessary cytokines when exhausted by oxidative stress