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In murine hypertrophic hearts models, the upregulated expression of mitochondrial protein sideroflexin 1 (SFXN1)mediates mitochondrial iron overload by transferring iron from the cytoplasm into the mitochondria, leading to excessive mitochondrial ROS production and increased lipid peroxidation, which triggers ferroptosis [232]

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The safety of using GHSs over the short and long term is According to a 2017 review, common side effects of using GHS may include: increased appetite elevated blood sugar levels fluid retention GHSs may also decrease the bodys sensitivity to the hormone insulin, making it more difficult to regulate blood sugar levels

Blood (1999) 93:161221