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Adverse Reactions/Side Effects The following adverse reactions are discussed elsewhere: Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen [see Warnings and Precautions (5.2)] Hypoglycemia [seeWarnings and Precautions (5.3)] Hypoglycemia Due to Medication Errors [see Warnings and Precautions (5.4)] Hypersensitivity Reactions [see Warnings and Precautions (5.5)] Hypokalemia [see Warnings and Precautions (5.6)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trial of another drug and may not reflect the rates observed in practice

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Furthermore, a reduced relative abundance of Akkermansia muciniphila has been shown to directly correlate with increased asthma severity, indicating that several specific bacteria affect disease severity in obese asthmatic patients (86)

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