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Hypersensitivity reactions may manifest in various ways, ranging from local injection site reactions such as erythema, swelling, and pruritus to more severe systemic reactions including angioedema, anaphylaxis, or generalized urticaria

In addition, these techniques require minimal training or supervision, making the delivery of semi-supervised home-based neuromodulation feasible [271], induce meaningful clinical effects from repeated sessions alone, and are highly amenable to experimentation, in both the basic and clinical research settings

The p53 protein is an endogenous regulator protein, considered to regulate the progression of the cell cycle, including cell death

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Int J Mol Sci 26:2691