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HSA-binding DARPin consists of two internal ankyrins with flanking constant N- and C-terminal capping repeats, each repeat forming a -turn followed by two anti-parallel -helix and an unstructured loop that binds to the -turn of the next ankyrin repeat (Fig

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Several drugs are in advanced clinical trials: In Phase III trials: IBI362 (Innovent/Eli Lilly), CagriSema (Novo Nordisk), Retatrutide (Eli Lilly), and Survodutide (Boehringer Ingelheim)

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