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doi: 10.1007/s12020-013-0121-x 88 DucciniKde SouzaMVLDelfimRAguiarAPTeixeiraPVaismanM

This sequence spans the region exhibiting a significant perturbation or notable increase in the hetNOE value

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Concurrently, hyperphosphorylation and its abnormal accumulation, coupled with impaired clearance, lead to the formation of NFTs, further compromising neuronal function