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Bile acidindependent flow (BAIF): Related to secretion of osmotically active reduced glutathione and bicarbonate into the canaliculus

A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) (Sorokin et al., 1986)

PMC11862975

294R501R509

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Gardiner SM, Kemp PA, March JE, Bennett T