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Notably, symptom improvements in prebiotic-treated males persisted at weeks 2 and 12, contrasting with transient effects in placebo-treated males (Voigt et al., 2025)

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Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide

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The success of insulin therapy for diabetes, growth hormone replacement for adult-onset deficiency, and GLP-1 receptor agonists for metabolic disease all demonstrate that exogenous peptides can meaningfully restore disrupted physiology