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Diabetes Obes Metab (2020) 22:313

Kynurenine pathway in depression: A systematic review and meta-analysis

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Specifically, melatonin suppresses proinflammatory cytokines (e.g., IL-1, IL-6, tumor necrosis factor- (TNF-), and interferon- (IFN-)) and enhances anti-inflammatory cytokines (e.g., IL-4 and IL-10) by inhibiting the NF-B pathway, although its low-dose transient proinflammatory effects highlight dose- and pathology-dependent dynamics

The study protocol was approved by the Institutional Review Board of Bhumibol Adulyadej Hospital and was registered in the Thai Clinical Trials Registry (TCTR)

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