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Diabetes Care 36 , 24892496 (2013)

Even so, there is still limited or uncertain evidence about their long-term safety, possible side effects, and how financial ties might influence study results

Use with Medications Known to Cause Hypoglycemia Sitagliptin As is typical with other antihyperglycemic agents used in combination with a sulfonylurea, when sitagliptin was used in combination with metformin and a sulfonylurea, a medication known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo in combination with metformin and a sulfonylurea [see Adverse Reactions]

17 Moreover, the effects of GLP-1 RAs on DR have been explored in many retrospective large database studies, which have also yielded conflicting results

However, its role has expanded, gaining popularity for weight loss capabilities