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Side effects like nausea or appetite loss are common early on but often improve

These effects are likely primarily mediated through actions in various regions of the brain involved in the regulation of appetite and food intake [18], as supported by preclinical studies [19,20,21,22], multiple human imaging studies [18], and the GLP-1R expression patterns in the human brain [9, 23]

Exenatide, when combined with metformin, has been shown to significantly suppress the proliferation of breast cancer cells [104]

Looking ahead, the momentum of GLP-1 innovation continues

26, Issue 15, 2025, Article 7239)

The metabolic benefits continue building without the tolerability challenges of the early weeks