In individuals with advanced -cell dysfunction, supplementing insulin therapy with pramlintide, the first and currently only approved injectable short-acting selective analog of amylin, has demonstrated efficacy in enhancing both postprandial and overall glycemic control in both type 2 diabetes (T2D) and type 1 diabetes (T1D) without increasing the risk of hypoglycemia or weight gain
Other frequent adverse effects are hypoglycaemia, particularly in patients with type 2 diabetes, and headache
studies reporting changes in patient weight from baseline
The researchers randomly assigned participants in equal numbers to four groups: a once-weekly semaglutide injection of 1 mg or a once-weekly tirzepatide injection of either 5 mg, 10 mg, or 15 mg
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Michal, Nature , The Impact of GLP-1 Receptor Agonist Liraglutide on Blood Pressure Profile, Hydration, and Natriuresis in Diabetic Patients with Severely Impaired Kidney Function