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Conventional T2D treatments, including Sodium-Glucose Co-transporter-2 inhibitors (SGLT2 inhibitors), metformin, sulfonylureas, dipeptidyl peptidase 4 inhibitors (DPP-4 inhibitors), and insulin, primarily focus on glycemic control but exert varying and often modest effects on the underlying inflammatory state (11)

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21 Insulin-like growth factor-1 (IGF-1) is the leading anabolic growth factor in cartilage and is important for structural maintenance via stimulation of cartilage matrix molecules