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The dose escalation exists precisely for this reason

[51] The developing endocrine system may be particularly sensitive to exogenous melatonin, and long-term safety data in pediatric populations remain limited

Women with OSA often present with atypical symptoms such as fatigue, mood disturbances, and insomnia rather than the loud snoring more commonly associated with OSA in men

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The condition results from complex interactions between gut motility, visceral hypersensitivity, intestinal permeability, and the gut-brain axis