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Both live and pasteurized forms of Akkermansia are safe and well-tolerated, but pasteurized versions may have enhanced benefits

The most promising GLP-1R agonist in terms of efficacy, adverse effects, convenience for patients, cost-effectiveness and risk of cardiovascular complications is semaglutide, which is the only GLP-1R agonist that can be administrated as both an oral and injectable formulation

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Another study, ATTAIN-MAINTAIN, explored switching from Zepbound or injectable Wegovy to once-daily oral Foundayo (orforglipron) or placebo

It also made a $100 million-plus deal to buy Sequence, a telehealth business that offers virtual prescriptions to patients for these weight loss drugs where appropriate

Blood sugar improvements (if relevant) tend to be significant by this point