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Then we have the ITT data

Unfortunately, glutathione can leak from microsomes, altering the [GSH]:[GSSG] ratio during their preparation, which would affect the values

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The SURMOUNT-1 trial (N=2,539), which evaluated tirzepatide 5, 10, and 15 mg, reported cholelithiasis in 1.6% of the tirzepatide arm versus 0.5% with placebo over 72 weeks