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At concentrations lower than those of DON, JHU395 has been found to decrease the growth and increase the apoptosis of high-MYC medulloblastoma cell lines, thereby prolonging the survival of treated animals ( GLS1 is the rate-limiting enzyme responsible for the breakdown of Gln

Some anti-depressants when used with vitamin B complex can cause panic which could be a potential effect of these vitamins on central nervous system

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