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Gharighnia S, Omidi A, Ragerdi Kashani I, et al

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Conclusion Our findings demonstrate a decrease in GSH levels with age in the PCC, but not other brain regions

Another more recently recognised variant is the lentiginous melanoma, which is similar to lentigo maligna but lacks the loss of rete ridges and occurs in middle-aged-and-older individuals on the upper arms and upper torso and after a protracted period might result in dermal invasion

The first-in-human Phase I clinical trial of JPH203 in patients with advanced solid tumors demonstrated improved therapeutic effects, particularly in two patients with CRC treated daily with intravenous JPH203 [73]