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Older adults ability to absorb B12 becomes compromised and a deficiency is more likely, says Gans

doi: 10.1111/j.1742-7843.2009.00480.x

Aherne C, Rapp C, Collins C, Mcnamee E, Jedlicka P, Eltzschig H (2016) P-124 migration of CD4 Th1 T cells to the inflamed intestine is suppressed by Netrin-1

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Sleep disturbance: If injecting late in the day, the energy boost may interfere with sleep

So it is not known if using them causes side effects and how serious they are. Beyond the immediate risks, theres a concern about hormonal disruption, especially for people with underlying health conditions, hormone sensitivity, or those who are pregnant or breastfeeding