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These trials offer valuable insights into the effectiveness of novel therapies and underscore significant progress in translational research
In vivo studies using a potassium oxonate/hypoxanthineinduced acute hyperuricemia model showed a significant hyperuricemia effect of compounds 55 , 56, and 58 , consistent with the in vitro inhibition results, but they did not show uric acidreducing activity as good as that of the drug febuxostat [72]
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Patients should not start MAOIs while taking hydrocodone bitartrate and acetaminophen tablets (see PRECAUTIONS, Drug Interactions)
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