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Prices are rising Prescription drug prices are climbing across the board with national drug spending growing 10 percent in 2024, outpacing other medical costs, while clinical drugs like infusions rose even faster at 14 percent

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It activates the GLP-1 receptor, which signals the pancreas to release insulin, slows gastric emptying, and reduces appetite.nnThree engineered changes to the native GLP-1 backbone (an Aib substitution at position 8, a Lys-to-Arg substitution at position 34, and a C18 fatty diacid attached at lysine 26) give semaglutide its long plasma half-life and once-weekly dosing profile

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In the STEP 1 trial of 1,961 adults with overweight or obesity, once-weekly semaglutide led to an average weight loss of about 14.9% of body weight over 68 weeks, against 2.4% for placebo

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