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These often improve as the body adjusts, but some people may experience persistent gastrointestinal discomfort

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At a normal therapeutic dose, acetaminophen is primarily metabolized by the liver to sulfate and glucuronide conjugates, while a SMALL amount is metabolized by CYP2E1 to a highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI)

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By the end of the trial period, average results showed: Those on a 4 mg dose lost 47.2 pounds (lb), or about 19 percent of their starting body weight