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Notably, GLP-1r activation in the VTA and NAc has been linked to a reduction in cocaine seeking behavior(Hernandez et al., 2018, 2017)
When that pathway is suddenly dampened, patients may feel: Less pleasure from eating Emotional blunting Frustration or irritability This is not the same as depression, but it can feel unsettling if not anticipated
CONCLUSION GLP-1 RAs play a pivotal role in various medical domains, ranging from glycemic control to cardiovascular health, neuroprotection, and potential applications in neurosurgery
& Haussler, D