When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure
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Luckily, the risks associated with a B12 deficient diet are generally well-known in vegan and vegetarian circles
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It causes oxidative damage to the cells lining blood vessels (endothelial cells), which promotes a hypercoagulable state
The Role of Vitamin B12 Vitamin B12 plays a crucial role in energy production, red blood cell formation, and maintaining a healthy nervous system