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Since there are known APOE -dependent differences in the gut microbiota in both humans and APOE-TR mice (Tran et al., 2019), L-carnitine metabolism could be impacted and, in turn, affect cerebrovascular function by disturbing normal L-carnitine shuttle function, particularly if other vulnerabilities are present

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Kaplowitz N (2005) Idiosyncratic drug hepatotoxicity

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The link between AMPK and PI3K pathways seems very important in muscle cells physiology, as androgens might promote muscle growth via PI3K/Akt, and energy metabolism through AMPK [99]