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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Supporting compounds are separate from GLP-1 drops and typically administered via injection at a different time of day

The wells were blocked with DPBS (pH 7.4)/4% (w/v) skimmed milk powder (Sigma-Aldrich) (PBS/M) (250 L/well) for 1 h at room temperature and washed three times with PBS/0.05% (v/v) Tween 20 (PBS/T) at either pH 5.5 or pH 7.4

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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily licensed for the treatment of type 2 diabetes mellitus and, more recently, obesity