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To delineate the tissue-specific contributions, we generated adipose- and liver-specific knockout models

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This disparity is hypothesized to arise from differences in estrogen-mediated neuroprotection, lifestyle factors, and occupational exposure to neurotoxins (Ben-Shlomo et al., 2024) (Figure 2)

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Lipid peroxidation plays a pivotal role in the pathogenesis of numerous diseases, including neurodegenerative disorders (e.g., Alzheimer's disease), cardiovascular diseases, and metabolic syndromes [54, 55]

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