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During the initiation stage, ROS may produce DNA damage by introducing gene mutations and structural alterations of the DNA

Given that ErbB contributes to IGF-IR/InsR and ER antagonist resistance, co-targeting ErbB, IGF-IR/InsR, and ER may achieve maximal anti-cancer effect on ER+ breast cancer [110]

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5-hmC increases markedly from the fetal to the adult stage and in the adult brain, which implies the importance of 5hmC in neuronal maturation and function [35]

This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability