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The "Long R3" refers to two key modifications: an arginine substitution at position 3 and a 13-amino acid N-terminal extension

For context, participants in the STEP 1 clinical trial taking 2.4 mg of semaglutide lost an average of 14.9% of their body weight over 68 weeks

Unlike generic copper salts or longer peptide fragments, GHK-Cu uniquely combines copper-mediated enzyme activation with peptide-driven signaling in a single molecule

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