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The peptide also promotes polarization of macrophages from pro-inflammatory M1 phenotypes toward tissue-repairing M2 phenotypes, with treated macrophages showing 70% increased phagocytic activity for clearing inflammatory debris and 3-fold higher production of VEGF compared to untreated controls

Radiosensitization of hypoxic tumour cells by S-nitroso-N-acetylpenicillamine implicates a bioreductive mechanism of nitric oxide generation

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doi: 10.1038/s41598-023-38696-4 107 LindahlSShiehMZhangTGuoCRobinsonJRSawaTet al

In fact, empirical evidence would seem to point to a potential weakness of the Reed-Nijhout model, that it ought to be modified to incorporate a higher Met blood leak