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Based on preclinical studies, a systematic review of the neuroprotective mechanisms of GLP-1RA-based therapy in ischemic stroke [67] has shown that administration of drugs of this family before, during, or after an experimental stroke in animals with and without diabetes modulates an acute inflammatory response secondary to brain ischemia, reducing inflammation, endothelial dysfunction and excitotoxicity, as well as decreasing oxidative stress and apoptosis

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Existen dos formas activas principales: GLP-1(7-36) amida con 30 aminocidos (la forma predominante en circulacin) y GLP-1(7-37) con 31 aminocidos

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@LillyPad #medtwitter #endotwitter pubmed.ncbi.nlm.nih.gov/35985340/ #retatrutide is a novel triple agonist peptide at the glucagon receptor, GIP receptor, and GLP-1 receptor

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