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CLINICAL PHARMACOLOGY Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight

The National Institute of Health has referred to it as one of the most feared complications of sedation and it can be fatal

MT-1 (Afamelanotide) has been studied and approved in some countries for the treatment of erythropoietic protoporphyria (EPP), a rare disorder that causes severe sensitivity to light

ii) Studies that were original research articles, including randomized controlled trials (RCTs) and protocol studies

Journal of Pharmacological and Toxicological Methods, 112 , 107127

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